Propofol Versus Dexmedetomidine on the Incidence of Postoperative Nausea and Vomiting

• Status: Recruiting
• Trial end date: 2023-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Post-operative nausea and vomiting are a leading cause of recovery room delays and low patient satisfaction. Complications such as suture line tension, wound hemorrhage and dehiscence, elevated intracranial pressure, pulmonary aspiration, dehydration, and electrolyte imbalance have been linked to nausea and vomiting.

Many studies were done to explore the effects of propofol and dexmedetomidine on the incidence of post operative nausea and vomiting (PONV). In this study, we will compare propofol infusion to dexmedetomidine infusion on the incidence of PONV in patients undergoing ureteroscopic procedures under spinal anesthesia in the age group from 18 to 60 years with more than one risk factor for PONV (female, history of PONV, non-smoking).

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• Patients aged 18 to 60 years

• ASA physical status I-II

• Scheduled for ureteroscopic procedure

• With more than one Risk factor for PONV (female, history of PONV, non-smoking).

Exclusion Criteria:

• Patients with contraindications for spinal anesthesia including infection at the injection site, bleeding diathesis, known left ventricular outflow obstruction, hypovolemia, and increased intracranial pressure.

• History of allergy or hypersensitivity to propofol or dexmedetomidine.

• Gastrointestinal diseases e.g. gastroenteritis and gastric ulcers, ear diseases e.g. infections of middle and inner ear, liver cirrhosis.

• Those who have received antiemetic drugs within 48 hours before surgery.

• Operations lasting more than two hours.

• The patient's unwillingness.