Propofol Versus Midazolam for Upper Endoscopy in Cirrhotic Patients

• Status: Completed
• Trial end date: 2009-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Upper GI endoscopy is often performed in patients with chronic liver disease to screen for esophageal and gastric varices. The purpose of this study is to compare propofol to midazolam for sedation in patients with chronic liver disease undergoing diagnostic upper GI endoscopy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ziv Hospital
• Treatments: Midazolam; Propofol

Criteria

Inclusion Criteria:

• Known chronic liver disease (Child-Pugh class A or B) who presented for upper GI endoscopy for routine variceal screening.

• The diagnosis of liver disease will be based on available past history, serological testing, radiological imaging, and liver histology when available.

• Staging of cirrhosis will be determined by MELD score and by Child-Pugh score . All patients will complete a standard preprocedure history and physical examination to establish current degree of encephalopathy and ascites.

Exclusion Criteria:

• Exclusion criteria will include the following:

• known allergy or adverse reaction to sedative or component thereof

• patients with known significant respiratory disease or airway abnormality)

• active neurological impairment including clinically detectable hepatic encephalopathy

• advanced or decompensated liver disease ( CP score >10, MELD >24) (Child-Pugh class C)

• active alcohol consumption or illicit drug abuse

• active prescription for sedation or narcotics