Propofol and Magnesium Sulfate Intravenous Infusion During Endoscopic Sinus Surgery

• Status: Unknown status
• Trial end date: 2020-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Endoscopic Sinus surgery usually associated by bleeding, despite using of local vasopressor injection, head up position- controlled hypotension is generally used for control of this purpose.

Propofol has been reported as a good agent for controlled hypotension by decreasing systemic vascular resistance secondary to arterial and venous vasodilation and a decrease in myocardial contractility with a dose-dependent property.

Magnesium Sulfate also has been reported as an agent of hypotensive anaesthesia by inhibition of the release of norepinephrine by blocking N-type calcium channel at the nerve ending beside acting as a vasodilator.

The well known pharmacodynamic effects of the intravenous infusion of propofol or Magnesium Sulfate may prove the advantage of this group in controlling intraoperative blood pressure thus reducing surgical field bleeding.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Atracurium; Fentanyl; Lidocaine; Magnesium Sulfate; Propofol

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists Physical Classes I or II

Exclusion Criteria:

• Patients refusal

• Patients with hypersensitivity for any drug used in the study including magnesium, propofol or isoflurane

• Patients receiving magnesium sulfate supplementation

• Patients receiving drugs known to have significant interaction.

• Patients with ischemic heart disease

• Patients with heart defects

• Patients with significant heart failure

• Patients with increased intracranial pressure.

• Patients with systemic hypertension