Propofol or Sevoflurane Anesthesia in Egyptian Patients

• Status: Recruiting
• Trial end date: 2023-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The proposed research in this application will investigate postoperative cognitive function, pain index, inflammatory response, and oxidative stress effects of propofol versus sevoflurane anesthetic drugs in patients undergoing elective, major, non-cardiac operations under general anesthesia to investigate which of them will significantly maintain better cognitive function, decrease the pain index, inflammatory reaction, and oxidative stress, improve outcome, shorten the postoperative recovery time and reduce length of hospital stay, and consequently the cost of hospital stay.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rehab Werida
• Treatments: Propofol; Sevoflurane

Criteria

Inclusion Criteria:

1. Patients who will be candidates for elective, major, non-cardiac operations under general anesthesia with propofol or sevoflurane.

2. Patients aged from 21 and older, of either sex.

3. Patients with body mass index (BMI) 25 to 35 kg/m².

4. Patients belong to the American Society of Anesthesiologist (ASA) physical status I or II.

5. Patients should have basically normal preoperative laboratory investigations.

Exclusion Criteria:

1. Patients with mini-mental state examination (MMSE) score <24 points.

2. Patients with significant cardiovascular, cerebrovascular, respiratory, liver, renal, endocrine, blood, or immune diseases.

3. Patients with visual or auditory disease, infection, chronic inflammation, disturbance of consciousness, cognitive impairment, or dementia.

4. Patients who are on long-term use of sedatives or steroids.

5. Alcohol or drug abuse.

6. Allergy to any drug will be used in this study.