Propofol vs Sevoflurane in Cyanotic Congenital Heart Disease

• Status: Recruiting
• Trial end date: 2021-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The stress response to surgery compromises a series of humoral, metabolic, or cellular reactions. Cardiac surgery with use of cardiopulmonary bypass (CPB) is a major activator of the systemic inflammatory response (SIRS). Inflammation, resulting in neutrophil activation, plays a central role in the production of reactive oxygen species (ROS). Inflammatory and oxidative reactions may play a role in the more frequent observation of postoperative ventricular dysfunction in patients with cyanotic congenital heart disease (CHD) undergoing surgery. The aim of this study is to compare the anti-inflammatory and anti-oxidative effects of propofol and sevoflurane in children with cyanotic CHD undergoing open heart surgery with CPB.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Cukurova University
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• 1-10 years old

• Patients with cyanotic congenital heart disease undergoing open heart surgery with CPB

Exclusion Criteria:

• Patients with liver or renal dysfunction

• Patients with inflammatory disease

• Patients with hemostatic disorders

• Preoperative use of anti-inflammatory and/or antioxidant drugs