Propofol's Hypnotic and Memory Effects

• Status: Completed
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to relate changes in the blood flow in your brain which are measured using magnetic resonance imaging (MRI) to temporary changes in your memory and level of sleepiness while receiving the drug propofol, which is commonly used to induce relaxation or sleepiness for minor surgical procedures. This study will help provide us information which will be useful in understanding which parts of the brain are influenced by these drugs to affect memory and sleepiness.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Memorial Sloan Kettering Cancer Center
• Collaborators: National Institute of General Medical Sciences (NIGMS); Weill Medical College of Cornell University
• Treatments: Hypnotics and Sedatives; Pharmaceutical Solutions; Propofol

Criteria

Inclusion Criteria:

• Healthy normal volunteers who show no evidence of neurologic deficit on questionnaire and physical examination

• Females of child-bearing age must be non-pregnant as demonstrated using a pregnancy test, non-lactating, and must be using adequate contraception or be surgically sterile

• Age 18 years to 45 years

• Right hand dominant

• High school education or above(to ensure consistent performance on the memory tests being administered)

• English as native language or equivalent degree of fluency

Exclusion Criteria:

• Any evidence of neurologic deficit including seizures, history of severe head trauma or any previously or current abnormal study of CNS - (eg. MRI, EEG, etc.)

• Any deficit in auditory or visual ability that would prevent performance of the study tasks

• History of claustrophobia

• Any history of hypertension (resting BP >150 systolic, >100 diastolic) or taking anti- hypertensive medication

• Any history of cardiovascular disease including previous myocardial infarction, arrhythmia, heart valve disease, or cardiac murmur

• Significant pulmonary, renal, gastrointestinal, or endocrine metabolic disease which in the opinion of the investigator would complicate the goals of this study

• Allergy to propofol, thiopental, eggs or history of acute intermittent porphyria, history of severe allergic reaction (e.g. anaphylactic shock)

• History of substance abuse

• Currently taking centrally acting medications (benzodiazepines or other anxiolytics, antidepressants, antipsychotic agents, or agents affecting the cerebral vasculature)

• Any one who is not NPO for at least 6 hours

• Any implant incompatible with MR scanning

• Anyone who, in the opinion of the investigators, would be unwilling or unable to tolerate the procedures and/or comply with the task instructions

• Body Mass Index (BMI) > 30