Overview

Propolis Improves Glycemic Control in Subjects With Type 2 Diabetes and Chronic Periodontitis

Status:
Completed
Trial end date:
2015-03-01
Target enrollment:
0
Participant gender:
All
Summary
Background: Propolis is a natural resin made by bees from various plant sources. Propolis exerts antimicrobial, anti-inflammatory, immunomodulatory, antioxidant, and antidiabetic properties. The purpose of this study was to assess the adjunctive benefit of propolis supplementation in individuals with both chronic periodontitis and type 2 diabetes mellitus (T2DM) receiving scaling and root planing (SRP). Methods: A 6-month randomized blinded clinical trial comparing SRP with placebo (placebo+SRP group, n=26) or combined with a 6- month regimen of 400 mg oral propolis once daily (propolis+SRP group, n=26) was performed in patients with long-standing T2DM and chronic periodontitis. Treatment outcomes included hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), serum N€-(carboxymethyl) lysine (CML) and changes in periodontal parameters.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Mohamed Anees
Collaborator:
Mansoura University
Treatments:
Propolis
Criteria
Inclusion Criteria:

- Patients had type 2 diabetes mellitus with a minimum of five years duration and had
been taking stable doses of oral hypoglycemic drugs and/or insulin for at least 6
months.

- Patients should have chronic periodontitis with probing pocket depth and clinical
attachment loss ≥ 5 mm with detectable bleeding on probing in at least one site in
each sextant.

- Patients should have a minimum of 20 teeth to be selected.

- All patients were diagnosed to have moderate to severe chronic periodontitis according
to Armitage criteria.

Exclusion Criteria:

- Smokers.

- Recent extended use of antibiotics or non-steroidal anti-inflammatory drugs within the
last 3 months.

- Patients who had any periodontal therapy within one year.

- Patients with grade 3 or 4 retinopathy.

- Pregnancy.

- Women using oral contraceptives.