Overview

Prospective Study of Fertility-sparing Treatment Strategy in Patients With Early Cervical Cancer(SYSUGO-005/CSEM009)

Status:
Recruiting

Trial end date:
2025-11-01

Target enrollment:
0

Participant gender:
Female

Summary

Patients with cervical cancer staging IB1-IIA2 desiring keeping their fertility function will be recruited. Before treatment, MRI scanning will be used to exclude retroperitoneal lymph node metastasis, involvement of lower part of uterus and endometrial carcinoma.If there is no macroscopic tumor and no obvious disease in MRI,simple trachelectomy (ST) + sentinel lymph node biopsy (SLNB) / retroperitoneal lymph node dissection(RPLND) will be performed. Otherwise,two to three cycles of neoadjuvant chemotherapy (NACT) will be administrated and then different fertility-sparing surgery(conization,ST or radical trachelectomy(RT) + SLNB/RPLND) will be employed depending on the tumor size.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Sun Yat-sen University

Treatments:

Cisplatin
Taxane

Criteria

Inclusion Criteria:

- patients with cervical cancer staging IB1-IIA2 desiring keeping their fertility
function

Exclusion Criteria:

- retroperitoneal lymph node metastasis, involvement of lower part of uterus and
endometrial carcinoma