Prospective Study of TW in the Treatment of LN Type V With Gross Proteinuria

• Status: Completed
• Trial end date: 2011-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to analyze the clinical effects and adverse reactions of tripterygium glycosides (TW) and CTX in LN-V patients with gross proteinuria.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Nanjing University School of Medicine

Criteria

Inclusion Criteria:

1. SLE patients aging 18-60 years, all of whom comply to the ISN/RPS classification.

2. Urine protein≥3.0g/24h, Alb<30g/L and Scr<1.5mg/dL.

3. All cases are type IV, confirmed by renal biopsy.

4. All patients sign the informed consent and be willing to follow-up on time

Exclusion Criteria:

1. Accepted drug therapy, such as CTX MMF CsA FK506 or TW more than 2 weeks in the latest 3 months.

2. Scr level above 1.5mg/dL, lasts more than 3 months.

3. Heart, lung or central nervous systems involved or combined with severe infection.

4. With liver function abnormal, ALT or AST being two times above the normal.

5. Pregnant women or patients still in lactation.