Prostate Specific Membrane Antigen (PMSA)-Based PET Imaging of High Risk Prostate Cancer
Status:
Recruiting
Trial end date:
2025-08-31
Target enrollment:
Participant gender:
Summary
Background:
People with prostate cancer usually have their cancer imaged with a CT scan and bone scan.
They then have their prostate gland removed. Researchers want to test a scan that might
predict if prostate cancer will return after this surgery.
Objective:
To test if a PET/CT scan before the prostate gland is removed can predict if prostate cancer
will return. Also, to test if this approach is better or worse than the usual approach for
prostate cancer.
Eligibility:
Men ages 18 and older with prostate cancer that appears to be contained within the prostate
but is at risk of having spread
Design:
Participants will be screened with:
- Medical history
- Blood tests
- CT and MRI scans: Participants will lie in a machine. The machine will take pictures of
the body.
- Bone scan
Participants will have a radiotracer injected into a vein. They will have a PET/CT scan of
their whole body 60 90 minutes later. During the scan, they will lie on their back and stay
still.
Within 60 days after the scan, participants will have surgery. This will remove the prostate
gland and lymph nodes around it. Some tissue will be used for genetic testing.
If the PET/CT scan suggests the cancer has spread, participants may need to have another
biopsy within 60 days after the scan.
After surgery, participants will have follow-up visits for 5 years. They will have 5 visits
the first year and 2 the second. Then they will have visits once a year.
If participants cancer returns, they will have repeat PET/CT scans.