Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT)
Status:
Unknown status
Trial end date:
2013-11-01
Target enrollment:
Participant gender:
Summary
The PIVOT trial aims to determine whether a strategy of switching to PI monotherapy is
non-inferior to continuing triple-therapy, in terms of the proportion of patients who
maintain all the drug treatment options that were available to them at baseline after at
least 3 years of follow-up, and to compare clinical events, safety, toxicity and health
economic parameters between the two strategies.
Phase:
Phase 4
Details
Lead Sponsor:
Medical Research Council
Collaborator:
NHS Health Technology Assessment Programme
Treatments:
Anti-Retroviral Agents HIV Protease Inhibitors Protease Inhibitors