Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing

• Status: Completed
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

A purpose of this protocol is to is to compare the metabolites of the toxic bioactivating pathway after acetaminophen alone or acetaminophen followed by Propylene Glycol (PG) and to determine if it prevents the formation of the toxic metabolites of acetaminophen.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Beth Israel Deaconess Medical Center
• Collaborator: Harvard University
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Healthy volunteers ages 20-40

• Patients not taking any chronic medications

Exclusion Criteria:

• Any history of liver disease

• Frequent alcohol use (2 or more drinks more than 4 times per week)

• Pregnant women

• Chronic medical condition requiring daily pharmacotherapy or the use of any daily prescription medications.

• Unable to provide informed consent