Prothrombotic Factors and Anaesthesia in Prostate Cancer

• Status: Completed
• Trial end date: 2014-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

This study aims to assess if different anesthetic techniques can affect coagulant factors in patients with prostate cancer undergoing elective laparoscopic radical prostatectomy (LRP).

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Regina Elena Cancer Institute
• Treatments: Anesthetics; Fentanyl; Midazolam; Propofol; Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

• newly diagnosed cancer of the prostate

• histological Gleason score evaluation.

Exclusion Criteria:

• ASA >2

• metabolic equivalent task < 4

• BMI>30

• no pre-operative pharmacological thromboprophylaxis and/or anti-coagulant therapy

• history of abnormal bleeding, or abnormal coagulant factors

• sepsis within the last 2 weeks

• previous new adjuvant treatments (chemo, hormone, and radiotherapy)

• non-steroid , anti-inflammatory and statins drugs for at least 2 wks before surgery

• venous or arterial thromboembolism within the last 3 months, peripheral venous disease

• neurological disease with extremity paresis

• chronic liver disease

• pre-operative haemoglobin concentration < 9 mg dl-1

• prolonged duration of surgery (>3 hrs)

• peri-operative blood transfusion

• not adequate material for laboratory testing