Overview

Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy

Status:
Recruiting
Trial end date:
2024-01-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this pragmatic interventional study is to evaluate whether a protocol-based management of antithrombotic drugs can reduce a composite of perioperative outcomes in patients with chronic antithrombotic therapy before surgery.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Peking University First Hospital
Criteria
Inclusion Criteria:

- 1. Patients with continuing antithrombotic therapy (including antiplatelet and/or
anticoagulant therapies) for cardiovascular and cerebrovascular diseases for more than
2 weeks.

- 2. Patients who have one or more of the following situations: (1) non-valvular atrial
fibrillation with a CHA2DS2-VASc score >4; (2) post-artificial valve replacement
(including mitral valve, ball-cage valve or tilting disc aortic valve); (3) venous
thromboembolism occurred within 1 year, or venous thromboembolism with other high-risk
factors which require long-term anticoagulation treatment; (4) coronary heart disease
with coronary stent implantation, thrombolytic therapy or other coronary procedures
within 2 years, or who had undergone coronary artery bypass grafting within 1 year, or
who experienced myocardial infarction or acute coronary syndrome within 1 year; (5) a
history of stroke/transient ischemic accident within 1 year, or a history of cervical
or intracranial revascularization treatment within 1 year; (6) peripheral arterial
disease.

- 3. Patients who are scheduled to undergo intra-abdominal surgery (including general
and urologic surgery).

- 4. Patients who sign written informed consents.

Exclusion Criteria:

- 1. Refuse to participate.

- 2. Emergency surgery.

- 3. Unable to complete the preoperative assessment and follow-up plan.

- 4. Other reasons that are considered unsuitable for study participation by the
investigators or the attending doctors.