Proton MR Spectroscopy and 18F-Fluorocholine PET for Breast Cancer Diagnosis
Status:
Unknown status
Trial end date:
2017-03-01
Target enrollment:
Participant gender:
Summary
The application of FCH PET in breast cancer diagnosis has not been reported.
We hypothesize that FCH reveals choline metabolic profiles of breast cancers, and shows the
similar pathophysiological mechanism to choline on proton MRS, and our study goals are:
1. To investigate and compare the diagnostic performance of proton MRS and FCH PET for
localized findings on mammography and breast ultrasound.
2. To investigate whether FCH PET findings are correlated with choline signals on proton
MRS.
3. To evaluate if choline, water and lipid signals on proton MRS, FCH PET are associated
with factors related to clinical outcome and prognosis- that is, molecular markers,
tumor staging, histologic grade of breast cancers.
4. For localized advanced breast cancer, to investigate the treatment response to NAC using
proton MRS and FCH PET, and to evaluate which modality is more sensitive.
5. To investigate the usefulness of FCH PET for whole body staging for breast cancer
patients.