Proton Pump Inhibitor Plus Propranolol Versus Proton Pump Inhibitor Alone on Peptic Ulcer Healing in Patients With Liver Cirrhosis

• Status: Terminated
• Trial end date: 2019-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Proton pump inhibitor plus propranolol versus proton pump inhibitor alone on peptic ulcer healing in patients with liver cirrhosis: a randomized trail

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Taipei Veterans General Hospital, Taiwan
• Treatments: Propranolol; Proton Pump Inhibitors; Rabeprazole

Criteria

Inclusion Criteria:

• Between 20 and 85 years old

• Liver cirrhosis associated with esophageal varices or gastric varices

• Gastric ulcer or duodenal ulcer ,size bigger or egual than 0.5 cm

Exclusion Criteria:

• Acute bleeding

• Steroid or NSAID user

• Pregnancy, or the patients with other terminal illness (such as other terminal cancers, heart failure, renal failure...)

• Propranolol contraindications (such as atrioventricular block, heart failure, chronic obstructive pulmonary disease, asthma, poorly controlled diabetes, severe peripheral arterial disease...)