Prucalopride for Postoperative Ileus in Patients Undergoing Gastrointestinal Surgery

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the effect and safety of prucalopride on recovery of gastrointestinal function in patient undergoing major gastrointestinal surgery. The investigators hypothesize that patients who take prucalopride after major gastrointestinal surgery will have shorter duration of postoperative ileus.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Jinling Hospital, China
• Treatments: Prucalopride

Criteria

Inclusion Criteria:

1. Consecutive patients undergoing elective gastric, small bowel, or partial colonic resection via laparotomy or laparoscopy.

2. Patients with American Society of Anaesthesiologists grading I-III

3. Informed consent available.

Exclusion Criteria:

1. Patients with stoma creation, extensive adhesiolysis, total or subtotal colectomy , or patients who had a history of total or subtotal colectomy.

2. Patients who developed intraoperative problems or complications, or had peritoneal carcinomatosis.

3. Patients who developed serious complications within 24 hours after surgery.

4. Those who received epidural anesthesia or analgesia.

5. Patients who received other prokinetic drugs.

6. Patients who were allergic to prucalopride.

7. Patients with severe comorbidity and/or organ(kidney, liver, and heart) dysfunction

8. Patients had complete bowel obstruction

9. Patients who have participated other clinical trials.

10. Patients who have short bowel(<200cm small bowel) or history of constipation.