This study evaluates whether psilocybin therapy helps patients cope with chronic low back
pain more effectively. Patients may be recruited at Stanford and University of California San
Francisco (UCSF), study procedures will occur at UCSF. Each participant will receive a dose
of psilocybin with possibly one or more other drugs. Participants will undergo two
preparation sessions, a dosing session, three integration sessions to discuss their
psilocybin experience, and several follow up sessions.