Psychopharmacotherapy for Depressive Patients

• Status: Recruiting
• Trial end date: 2030-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The primary purpose of this study is to compare the short (12 week) and long-term (1-year) efficacy and the tolerability between stepwise psychopharmacotherapy and antidepressant monotherapy for 12 weeks in adult patients with major depressive disorders, stratified by the multimodal serum biomarker scores.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chonnam National University Hospital
• Treatments: Antidepressive Agents; Aripiprazole; Citalopram; Dexetimide; Escitalopram; Mirtazapine

Criteria

Inclusion Criteria:

• 19 to 65 years

• Diagnostic and Statistical Manual of Mental Disorders-IV criteria for major depressive disorder by study psychiatrists

• Score≥17 on Hamilton Depression Rating Scale-17

• With ability to understand the objective of the study and sign informed consent

• Initiation of an antidepressant treatment for the current episode or no psychotropics excluding sleep pills or benzodiazepines within 1 month of participation

Exclusion Criteria:

• Current or lifetime diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, schizophreniform disorder, psychotic disorder not otherwise specified, or other psychotic disorders

• current major depressive disorder with psychotic features

• History of organic psychosis, epilepsy, or seizure disorder

• Current anorexia nervosa or obsessive compulsive disorder

• Unstable or uncontrolled medical condition

• Unable to complete the psychiatric assessment or comply with the medication regimen due to a severe physical illness

• History of anticonvulsant treatment

• Electroconvulsive therapy for the current depressive episode

• Hospitalization for any psychiatric diagnosis except depressive disorder (e.g., alcohol/drug dependence)

• severly high risk of suicide, self-harm or homicide by investigator's assessment

• Pregnant or breastfeeding

• lack of treatment information on the current depressive episode