Psychostimulants Effects on Brain Functional Connectivity in Youth With Attention Deficit Hyperactivity Disorder
Status:
Unknown status
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
In the current study, we will administer three widely administered cognitive tasks while
simultaneously measuring electroencephalography (EEG) in ADHD patients before and after
methylphenidate immediate release (IR) treatment compared to placebo. In addition we will
compare the effective connectivity dynamics to normal subjects. Using this novel network
analysis approach, we will attempt to address the currently limited cognitive network
literature. We will attempt to map the connectivity between the discrete brain regions during
the execution of the tasks before and after treatment with methylphenidate IR. Comparison
with healthy control subjects will enable us to determine whether the direction of
methylphenidate induced changes in brain functioning (in youths with ADHD) will be toward or
away from normal connectivity patterns. We will also examine whether network patterns differ
between the healthy controls and the ADHD patients.