Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia
Status:
Completed
Trial end date:
2004-01-01
Target enrollment:
Participant gender:
Summary
Studies in the 1970s and 1980s suggested that the outcome of childhood acute lymphoblastic
leukemia could be improved by intensification of conventional continuation chemotherapy with
pulses of vincristine sulfate and steroids. We aimed to investigate the efficacy and toxic
effects of vincristine-dexamethasone pulses as an addition to the continuation-therapy phase
in a large cohort of children with intermediate-risk disease who were treated with the BFM
treatment strategy
Phase:
Phase 4
Details
Lead Sponsor:
International BFM Study Group
Collaborators:
Associazione Italiana Ematologia Oncologia Pediatrica BFM-A, Austria BFM-G, Germany and Switzerland CPH, Czech republic European Organisation for Research and Treatment of Cancer - EORTC GATLA, Argentina Group for Acute Leukemia Treatment (GATLA). H-POG (Hungary Pediatric Oncology Group) H-POG, Hungary PINDA, Chile