Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
Status:
Not yet recruiting
Trial end date:
2023-08-30
Target enrollment:
Participant gender:
Summary
This study will establish the relationship between magnitude of opioid exposure and a
pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged
40-60. Previous investigation demonstrated that loss of PUAL was a sensitive, discriminative
indicator of opioid toxicity and respiratory depression among subjects aged 20-40 years old.
Population data indicate that pupil size and PUAL decline slightly with age. The
investigators will explore whether PUAL proves to be a sensitive indicator of opioid exposure
and respiratory depression in this older group.