Pupillography as Screening Tool for Brain Insulin Resistance

• Status: Completed
• Trial end date: 2019-01-07
• Target enrollment: 0
• Participant gender: All

Summary

Cerebral insulin action is important in the regulation of whole body glucose metabolism. However, the cerebral insulin action differs between individuals - there is a so called cerebral insulin resistance. The influence of central insulin action on peripheral metabolism seems at least partially mediated via the autonomous nervous system. A noninvasive method to measure autonomic function is the pupillography. The aim of the study is to find out whether pupillography can be used to assess central insulin activity. Thus, pupillography will be performed in 30 normal weight and 30 overweight subjects before and after application insulin intranasally.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital Tuebingen
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• voluntary adults

• HbA1c <5.8%

• Age between 18 and 60 years

• written consent

Exclusion Criteria:

• There is a pregnancy or pregnancy can not be excluded

• lactating women

• Minors or non-consenting subjects are also excluded

• Acute illness or infection within the last 4 weeks

• Neurological and psychiatric disorders

• intake of centrally acting drugs

• Subjects with hemoglobin levels Hb <12g / dl (in females), Hb <14g / dl (males)

• Allergic diseases against one of the substances used