Pupillography as Screening Tool for Brain Insulin Resistance
Status:
Completed
Trial end date:
2019-01-07
Target enrollment:
Participant gender:
Summary
Cerebral insulin action is important in the regulation of whole body glucose metabolism.
However, the cerebral insulin action differs between individuals - there is a so called
cerebral insulin resistance. The influence of central insulin action on peripheral metabolism
seems at least partially mediated via the autonomous nervous system. A noninvasive method to
measure autonomic function is the pupillography. The aim of the study is to find out whether
pupillography can be used to assess central insulin activity. Thus, pupillography will be
performed in 30 normal weight and 30 overweight subjects before and after application insulin
intranasally.