Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults
Status:
Completed
Trial end date:
2021-06-01
Target enrollment:
Participant gender:
Summary
Previous research has identified adenosine triphosphate (ATP) as an important vasodilator
that is released from red blood cells during exercise and exposure to hypoxic environments in
adult humans. Further, older adults appear to have lower blood flow during both of these
stressors and also have lower amounts of ATP released from their red blood cells. However,
the contribution of ATP to vasodilation in response to exercise and hypoxia is currently
unknown due to the lack of an effective ATP receptor antagonist. We aim to determine whether
Vitamin B6 or its metabolite, Pyridoxal-5-Phosphate (PLP) is an effective ATP receptor
antagonist.
Phase:
Early Phase 1
Details
Lead Sponsor:
Colorado State University
Treatments:
Acetylcholine Adenosine Nitroprusside Pyridoxal Pyridoxal Phosphate Pyridoxine Vitamin B 6 Vitamin B Complex Vitamins