Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults

• Status: Completed
• Trial end date: 2021-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Previous research has identified adenosine triphosphate (ATP) as an important vasodilator that is released from red blood cells during exercise and exposure to hypoxic environments in adult humans. Further, older adults appear to have lower blood flow during both of these stressors and also have lower amounts of ATP released from their red blood cells. However, the contribution of ATP to vasodilation in response to exercise and hypoxia is currently unknown due to the lack of an effective ATP receptor antagonist. We aim to determine whether Vitamin B6 or its metabolite, Pyridoxal-5-Phosphate (PLP) is an effective ATP receptor antagonist.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Colorado State University
• Treatments: Acetylcholine; Adenosine; Nitroprusside; Pyridoxal; Pyridoxal Phosphate; Pyridoxine; Vitamin B 6; Vitamin B Complex; Vitamins

Criteria

Inclusion Criteria:

• Sedentary-moderately active

• Free of chronic disease

Exclusion Criteria:

• Current smoker

• BMI > 29.9 kg/m2

• Blood pressure equal to or greater than 140/90 mmHg

• Use of any medications including vitamin B6 supplements or antioxidants