Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma
Status:
Recruiting
Trial end date:
2029-01-01
Target enrollment:
Participant gender:
Summary
Oropharyngeal squamous cell carcinoma (OPSCC) is now the most frequently diagnosed head and
neck cancer in Denmark which is mainly due to the increase of Human Papillomavirus (HPV).
Patients with HPV-positive OPSCC have a significantly higher survival rate compared to
HPV-negative OPSCC. The traditional primary treatment modality in Denmark is Intensity
Modulated Radiation Therapy (IMRT), and in advanced stages in combination with chemotherapy.
Since 2009, Transoral Robotic Surgery (TORS) has enabled surgeons to perform minimally
invasive surgery as an alternative to standard radiotherapy treatment which is considered the
primary treatment for OPSCC in many countries. There is a lack of randomised trials comparing
long-term functional outcomes after TORS or IMRT. Current data are mostly derived from
retrospective studies with selection bias. However, several small retrospective studies have
shown promising results when comparing the two treatment modalities in favour of TORS with
regards to treatment related swallowing function and quality of life (QoL) without
compromising survival outcomes.
This study aims to evaluate the early and long-term functional outcomes following two
treatment arms 1) TORS combined with neck dissection and 2) IMRT±concurrent chemotherapy with
a special focus on swallowing-related QoL.
Phase:
N/A
Details
Lead Sponsor:
Christian von Buchwald
Collaborators:
Aarhus University Hospital Herlev Hospital Naestved Hospital Odense University Hospital