Quality of Life in Patients With Statin-Associated Myopathy
Status:
Terminated
Trial end date:
2013-02-01
Target enrollment:
Participant gender:
Summary
The proposed study will focus on possible effects of statins on muscle strength and why they
become tired more easily, quality of life, and measurements to understand why muscles are not
able to fully utilize fats. The investigators are specifically interested in statin users and
the impact of muscle symptoms on daily activities and quality of life.
This study hypothesize that patients with likely statin-associated myopathy have a metabolic
dysregulation in fuel utilization such that compared to patients continuing statins, those on
placebo will show:
1. improved Individualized Neuromuscular Quality of Life (INQoL) and Short Form-36 (SF-36)
scores (primary end point)
2. alleviation of muscle symptoms,
3. increased utilization of fatty acids as a fuel source reflected by the metabolic test
results
4. decreased intramyocellular lipid (IMCL)
5. improved insulin sensitivity.