Quantification of Dynamic and Static Cerebral Autoregulation (CA) Under Anaesthesia
Status:
Completed
Trial end date:
2019-09-23
Target enrollment:
Participant gender:
Summary
Cerebral autoregulation (CA) is the mechanism by which the brain vasculature maintains
constancy of cerebral blood flow (CBF). Reliable direct measurements of CBF at different
blood pressure levels are difficult because they are invasive and time-consuming. This type
of measurement to quantify CA is generally referred to as static cerebral autoregulation
(sCA). Alternatively, it is possible to measure CA indirectly from blood pressure
oscillations. Dynamic cerebral autoregulation (dCA) measures how quickly the cerebral vessels
react to a change in blood pressure to normalize CBF. Since the introduction of transcranial
Doppler ultrasound (TCD), it has become possible to estimate CBF velocity relatively easy,
which in turn correlates well with CBF changes. This method is widely used to quantify dCA.
However, it is not clear how sCA correlates with dCA over a range of physiologic mean blood
pressure (MBP). It is important to compare different methods of assessing CA, because
impaired CA may result in increased risk of perioperative complications such as stroke. In
this study, the investigators were interested in establishing the relationship between sCA
and dCA during surgery under general anesthesia. The investigators aim to compare these
methods during propofol and sevoflurane anesthesia.
Phase:
N/A
Details
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)