Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study
Status:
Recruiting
Trial end date:
2025-12-31
Target enrollment:
Participant gender:
Summary
QARIN 1 is a study of [18F]DPA-714 Translocation Protein (TSPO) Positron Emission Tomography
(PET) for longitudinal, quantitative assessment of brain neuroinflammation following whole
brain radiation therapy. This TSPO PET, uses a radioactive tracer. An optional MRI (magnetic
resonance imaging) will also be performed to monitor brain microstructure damages induced by
neuroinflammation.
Primary Objectives
- Assessment of temporal and regional variability of uptake of translocator protein (TSPO)
positron emission tomography (PET) tracer.
- Regional variability will be assessed in medial temporal lobe, frontal lobe, and in
white matter
- Temporal variability will be assessed by scanning each subject four-times: at baseline
(before or within 2 weeks of start of radiation therapy), before start of chemotherapy,
at 1 year from the initiation of the radiation therapy, and at 1.5-2 years from the
initiation of the radiation therapy
- Correlation of radiation dose in specific brain regions with radiation induced
neuroinflammation as measured by uptake of TSPO PET tracer.
Exploratory Objectives
- Assessment of radiation-induced brain microstructure injuries (RIBMI) in specific brain
regions (medial temporal lobe, frontal lobe, and in white matter) using advanced
magnetic resonance imaging (MRI) techniques.
- Association of radiation dose with MRI measures of RIBMI in these specific brain
regions.
- Association of PET measures of RIN with MRI measures of RIBMI.
- Association of PET measure of RIN and MRI measures of RIBMI in specific regions of
interest (ROI) with specific domain of neuro-cognition. For example, to investigate
whether PET measure of RIN and MRI measures of RIBMI in hippocampal ROI have strongest
association with episodic memory; whether frontal lobe cortical ROI are associated with
attention and executive function.
- Association of a novel MRI based technique for assessment of RIN with TSPO PET.
- Association of the PET and MRI measure of neuroinflammation within 2- years of
completion of radiation with delayed cognitive outcome that will be measured at 3, 4 and
5 years from the completion of radiation