Quetiapine Augmentation Versus Clomipramine Augmentation of SSRI for Obsessive-compulsive Disorder Patients

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this trial is to compare in an open trial format the efficacy of association of clomipramine and quetiapine with SSRI after SSRI treatment failed to produce complete remission of obsessive compulsive disorder symptoms.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo
• Collaborator: Conselho Nacional de Desenvolvimento Científico e Tecnológico
• Treatments: Clomipramine; Quetiapine Fumarate; Serotonin Uptake Inhibitors

Criteria

Inclusion Criteria:

• primary OCD diagnosis according to DSM IV criteria

• current symptoms were responsible for significant distress

• previous trial of at least 12 weeks with SSRI (being at least 8 weeks at maximum tolerated dosage) failed to produce full remission of OCD symptoms

Exclusion Criteria:

• presence of clinical or neurological diseases that may be worsen by the medications included in treatment protocol

• current substance dependence or abuse,

• current psychotic symptoms

• current suicide risk

• and current pregnancy or intention to get pregnant before the end of the treatment protocol