Overview

Quetiapine Versus Haloperidol in the Management of Hyperactive Delirium

Status:
Recruiting

Trial end date:
2023-01-15

Target enrollment:
0

Participant gender:
All

Summary

In population of intensive care unit (ICU), most studies compared atypical antipsychotics such as quetiapine with the traditional haloperidol in delirious patients of various forms and etiologies. The role of such agents in patients with hyperactive is not fully understood. This study compares the effectiveness of quetiapine with haloperidol in treating the hyperactive form of delirium in terms of their effects on morbidity, length of stay in the intensive care unit, and mortality in critically ill patients.

Phase:

Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Alexandria University

Collaborators:

Gezira University
Suez Canal University

Treatments:

Haloperidol
Haloperidol decanoate

Criteria

Inclusion Criteria:

- All patients who are diagnosed with hyperactive form of delirium during their ICU stay
using CAM-ICU tool (the confusion assessment method for the intensive care unit)

Exclusion Criteria:

- Suspected substance-induced delirium

- Previous use of antipsychotics

- Known allergy or intolerance to the study drugs

- Pregnancy or breast feeding

- Acute renal injury

- Hepatic failure

- Inability to tolerate oral drugs