Quinidine Versus Verapamil in Short-coupled Idiopathic Ventricular Fibrillation
Status:
Recruiting
Trial end date:
2025-10-01
Target enrollment:
Participant gender:
Summary
Short-coupled idiopathic ventricular fibrillation (IVF) is a rare subtype of idiopathic
ventricular fibrillation that is characterized by ventricular fibrillation (VF) or
polymorphic ventricular tachycardia (PVT) initiated by a short-coupled premature ventricular
contraction (PVC). Although patients are protected from sudden cardiac death by an
implantable cardioverter-defibrillator (ICD), additional antiarrhythmic drug therapy is
indispensable as recurrent ICD shocks are not uncommon and can negatively affect quality of
life. Verapamil and quinidine have been suggested as effective antiarrhythmic drugs, but at
present it is unknown whether these drugs reduce the incidence of arrhythmic events. This
pilot study will provide insight into the advisability and feasibility of a randomized
controlled trial (RCT) and provide data needed to determine the most appropriate design and
the sample size.
Phase:
Phase 2
Details
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)