R-CHOP Versus R-mini-CEOP in Elderly Patients(>65)With DLBCL

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The study has the purpose to compare R-CHOP versus R-mini-CEOP in elderly patients (>65 years) with Diffuse Large B Cell Lymphoma (DLBCL).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fondazione Italiana Linfomi ONLUS
• Treatments: Cyclophosphamide; Doxorubicin; Epirubicin; Liposomal doxorubicin; Prednisone; Rituximab; Vinblastine; Vincristine

Criteria

Inclusion Criteria:

1. Patients with untreated DLBCL aged 66 to 80 years without major accompanying diseases and considered as "non frail".

2. Patients were classified as "non frail" (fit) if they had

• ADL (Activity of Daily Living) score of 6

• less than three grade 3 Cumulative Illness Rating Score for Geriatrics (CIRS-G) co-morbidities and no grade 4 co-morbidities

• absence of geriatric syndrome

3. Patients HIV negativity;

4. Concurrent malignancy;

5. Written Informed Consent.

Exclusion Criteria:

• All other patients were classified as "unfit", and were excluded from randomization