R230C and C230C Variants of ABCA1 and Glyburide Response

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of the study is to know if the R230C and C230C variants of the ATP-binding cassette transporter A1 (ABCA1) gene are associated with a smaller glucose lowering effect compared to the wild type allele (R230R) in patients with type 2 diabetes.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
• Treatments: Glyburide

Criteria

Inclusion Criteria:

• Adults 20 to 79 years

• Body mass index >18 and 39.9 ≤

• Men or women

• Mexicans mestizos.

• Moderate hyperglycemia (126 to 250 mg/dl and HbA1c levels between 7 and 10%) despite being treated with a dietary program in combination or not with metformin (2 g/d).

Exclusion Criteria:

• Patients with chronic complications of diabetes: ischemic heart disease, stroke, proliferative retinopathy or blindness, albuminuria, chronic diarrhea, gastroparesis, non-traumatic amputation of lower limbs.

• Patients with any monogenic syndrome, obesity, diabetes or hypoalphalipoproteinemia

• Patients with acquired diseases that produce secondarily obesity or diabetes.

• Treatment with anorexigenics or accelerate weight loss at the time of the selection.

• Cardiovascular event in the 6 months prior to study entry.

• Steroids, chemotherapy, immunosuppressive or radiotherapy.

• Infections or concurrent acute diseases.

• Catabolic diseases such as cancer or AIDS

• Pregnancy