RA Effect on Cell Surface Molecules in Vivo

• Status: Withdrawn
• Trial end date: 2019-05-08
• Target enrollment: 0
• Participant gender: Male

Summary

This study will follow a group of healthy male participants for about 18 weeks to see the effect of taking Acitretin on their immune cells

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ottawa Hospital Research Institute
• Treatments: Acitretin

Criteria

Inclusion Criteria:

1. Male gender

2. Age 18 - 65

3. Able to provide informed consent

4. Willingness to participate in study treatment and follow-up

5. Willingness for serial phlebotomy and storage and future viro-immunological assays

Exclusion Criteria:

1. Female gender

2. Participants with a known hypersensitivity/allergy to the acitretin.

3. Participants who are actively participating in an experimental therapy study or who have received experimental therapy within the last 1 year.

4. Participants who are a poor medical risk because of other systemic diseases or active uncontrolled infections including HIV, Hepatitis B or C, and tuberculosis

5. Participants with impaired glucose tolerance including prediabetes or diabetes mellitus, dyslipidemia, or liver dysfunction

6. Previous or current history of mood disorder, psychosis, or suicidality

7. Participants currently receiving ongoing treatment with methotrexate, tetracyclines, or other retinoids