RAS-Peptide-Profile Study in Healthy Male Subjects
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The primary objective is the characterization of the RAS peptide profiles after single and
repeated oral administration of a renin inhibitor, an ACE inhibitor and an angiotensin
receptor blocker in healthy volunteers.
Secondary objectives are the correlation of RAS peptide profiles with pharmacokinetic
profiles of the different RAS inhibitors and with pharmacodynamic parameters such as blood
pressure and heart rate. Output of the classic RAS system will be assessed using aldosterone
concentrations. Fluid and sodium intake will be monitored using sodium concentration and
total volume in 24h urine.