RATe Control in Atrial Fibrillation

• Status: Completed
• Trial end date: 2010-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the effect of metoprolol, verapamil, diltiazem and carvedilol on ventricular rate, working capacity and quality of life in patients with chronic atrial fibrillation.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Asker & Baerum Hospital
• Treatments: Carvedilol; Diltiazem; Metoprolol; Verapamil

Criteria

Inclusion Criteria:

• Persistent or permanent atrial fibrillation with ventricular rate > 80/min at rest and/or > 100/min average at daytime.

• Male or female, age > 18.

Exclusion Criteria:

• Hypersensitivity or contraindication to metoprolol, verapamil, diltiazem or carvedilol.

• Coronary heart disease or heart failure

• Systolic blood pressure < 100 mmHg

• AV-conduction disturbance

• Severe hepatic or renal dysfunction

• Thyrotoxicosis

• Ongoing treatment with Digitalis

• Pregnancy or lactation