RBC Lifespan Measurement in Diabetic Children

• Status: Recruiting
• Trial end date: 2022-09-01
• Target enrollment: 0
• Participant gender: All

Summary

HbA1c, a measure of mean blood glucose over the lifespan of a red blood cell (RBC), is a marker of increasing importance both for assessing glycemic control in children with known diabetes and for the diagnosis of diabetes in children. HbA1c has demonstrated poor reliability in diagnosis and management of pediatric diabetes and the most plausible reason for this unreliability is that the reference ranges of HbA1c were established based on 120-day RBC lifespan observed in adults, without considering the RBC lifespan difference between children and adults. The proposed studies will for the first time determine RBC lifespan in diabetic children

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guohua An; University of Iowa
• Treatments: Biotin

Criteria

Inclusion Criteria:

• children with either type1 or type 2 diabetes between 4-18 years old

Exclusion Criteria:

• consumption of biotin supplements or raw eggs within 30 days;

• history of gastrointestinal blood loss;

• heart failure ;

• active viral or bacterial infection;

• hemoglobinopathy;

• prior history of liver disease with transaminases more than 3 times the upper limit of normal for age;

• uncontrolled thyroid disease;

• anemia (whole blood HCT<33);

• history of renal disease (prior serum creatinine more than >1.5 mg/dlL);

• detectable antibody to biotin.