RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ)
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
The objective of this study is to evaluate the effectiveness of trazodone as compared to
quetiapine and placebo, in the management of ICU delirium in adult (>=18 years old) surgical
ICU patients. The investigators will compare outcomes such as delirium incidence and
duration, in-hospital mortality, 28-day mortality, hospital length of stay (LOS), ICU LOS,
mechanical ventilator days, complications, adverse effects, rescue medication use, delirium
symptom severity, sleep duration, and sleep quality among participants receiving trazodone,
quetiapine, or placebo. The investigators hypothesize participants receiving trazodone will
have a shorter duration of delirium, decreased delirium severity, and improved sleep quality
compared to participants receiving quetiapine and placebo.