RCT of a Neuroplasticity Agent and CI Therapy for Severe Arm Paresis After Stroke
Status:
Withdrawn
Trial end date:
2021-11-01
Target enrollment:
Participant gender:
Summary
Stroke patients who have little or no voluntary movement in the hand on the more affected
side of their body more than one year after stroke have few treatment options. This project
proposes to test the efficacy of a form of Constraint-Induced Movement therapy designed for
patients with such severe impairment in conjunction with an agent, fluoxetine, which has been
shown in some studies to enhance brain neuroplasticity in response to training.
Constraint-Induced Movement therapy, which is abbreviated CIMT, is a form of physical
rehabilitation based on basic research in neuroscience and behavioral science. If the project
is successful, an efficacious, evidence-based therapy will become available to stroke
patients for what is now a largely untreated condition