RESTORE: buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

• Status: Not yet recruiting
• Trial end date: 2025-04-30
• Target enrollment: 0
• Participant gender: All

Summary

RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, San Francisco
• Collaborator: The ZOLL Foundation
• Treatments: Anesthetics

Criteria

Inclusion Criteria:

1. Age ≥18 years old

2. Non-traumatic, out-of-hospital cardiac arrest

3. Comatose on admission - defined as not following commands

4. Return of spontaneous circulation (ROSC) within less than 45 minutes

5. Admission to the intensive care unit

6. Diagnosis of post-cardiac arrest refractory status epilepticus confirmed with continuous

EEG monitoring within 7 days from ROSC

Exclusion Criteria:

1. Acute cerebral hemorrhage or infarction

2. Pregnancy

3. Prisoners