RIC Regimen for Elderly or High Comorbidity Burden Patients Receiving Haplo-HSCT
Status:
Recruiting
Trial end date:
2021-09-01
Target enrollment:
Participant gender:
Summary
This study aimed to evaluate the efficacy of reduced intensity conditioning (RIC) regimen in
elderly or high comorbidity burden patients who receive haploidentical hematopoietic stem
cell transplantation (haplo-HSCT). Haplo-HSCT is an effective treatment option for patients
who did not have identical sibling donor (ISD) or unrelated donor (URD). However,
post-transplant transplant-related mortality (TRM) is one of the major causes for transplant
failure, and the risk of TRM for old patients or those with high comorbidity burden was
higher. RIC regimen may decrease the risk of TRM for haplo-HSCT recipients. The study
hypothesis: Using RIC haplo-HSCT regimen in elderly patients or those with high comorbidity
burden can reduce TRM and improve survival.