Race, Natriuretic Peptides and Physiological Perturbations

• Status: Recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to understand the origins of differential response to beta-blockers in African-Americans and may provide insight regarding racial differences in cardiovascular risk.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alabama at Birmingham
• Treatments: Metoprolol

Criteria

Inclusion Criteria:

• 18 to 40 years

• Blood pressure less than 140/90 mm Hg

• Able to perform exercise capacity test

• BMI 18-25 kg/m2

• Willing to adhere to study drug

Exclusion Criteria:

• History of cardiovascular disease or use of medications for CVD

• History of hypertension or use of BP lowering medications

• Blood pressure less than 100/60 mm Hg

• Heart rate less than 60 beats/min

• Depression

• Diabetes or use of anti-diabetic medications

• Renal disease (eGFR < 60ml/min/1.73m2)

• Current or prior smokers

• Pregnant or use of Hormone Replacement Therapy (HRT) or oral contraceptives (OCP) or steroids