Radial Artery Dilation Study: The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The radial artery, which is located on the outer side of the forearm, can be used in interventional procedures, such as cardiac catheterization, to provide access to the arterial blood supply. In order to facilitate successful catheterization of the artery, a dilated artery and one free of arterial spasm is desirable. The proposed study will randomize twenty three healthy subjects in 2 visits to determine the effect of topical nitroglycerin on radial artery vasodilation. Radial artery diameter will be measured with ultrasound at regular intervals up to two hours.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, San Francisco
• Treatments: Lidocaine; Nitroglycerin

Criteria

Inclusion Criteria:

• Willing and able to give written informed consent and comply with study requirements

• Patient who speak English

Exclusion Criteria:

• Presence or history of liver, cardiovascular, rheumatologic, cancer or renal disease.

• Current treatment with any vasodilator therapy

• Systolic blood pressure of less than 90 mmHg

• History of radial artery catheterization within the previous year

• Absence of radial artery blood flow in one or both arms

• Pregnancy.

• Active infection

• Staff members of the Cardiac Catheterization Laboratory.