Overview

Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer

Status:
Completed
Trial end date:
2005-07-01
Target enrollment:
0
Participant gender:
Male
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether chemotherapy is more effective than radiation therapy for testicular cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of carboplatin with that of radiation therapy in treating patients who have stage I testicular cancer.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Medical Research Council
Collaborator:
European Organisation for Research and Treatment of Cancer - EORTC
Treatments:
Carboplatin
Criteria
DISEASE CHARACTERISTICS: Histologically confirmed stage I seminomatous germ cell tumor of
the testis categorized as either "classical" or "anaplastic"

PATIENT CHARACTERISTICS: Age: 16 and over Performance status: Not specified Hematopoietic:
Not specified Hepatic: Not specified Renal: Creatinine less than 1.4 mg/dL Other: No
concurrent or previously treated malignancy except successfully treated nonmelanoma skin
cancer No medical condition or other factor that would preclude study

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Not specified
Endocrine therapy: Not specified Radiotherapy: Not specified Surgery: No more than 8 weeks
since prior orchidectomy Prior inguino-pelvic or scrotal surgery allowed Must be treated
with "dog-leg" field if randomized to radiotherapy If prior vasectomy, choice of fields is
at the discretion of the clinician