Radiation Therapy Plus Chemotherapy in Treating Patients With Pancreatic Cancer

• Status: Completed
• Trial end date: 2007-06-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy combined with chemotherapy may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of brachytherapy followed by external-beam radiation therapy plus chemotherapy in treating patients who have pancreatic cancer that cannot be removed surgically.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Center for Molecular Medicine
• Treatments: Dexamethasone; Fluorouracil

Criteria

DISEASE CHARACTERISTICS:

• Histologically proven unresectable adenocarcinoma of the pancreas limited to the head, body, or tail of the pancreas

• Diameter no greater than 5 cm

• Volume no greater than 66 mL

• No ascites (with or without tumor cells)

• No endoscopically proven tumor penetration of duodenum or stomach

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• Karnofsky 70-100%

Hematopoietic:

• WBC at least 3,000/mm3

• Platelet count at least 100,000/mm3

• Hemoglobin at least 9 g/dL (transfusion allowed)

Hepatic:

• No hepatic disease

• At least 50% uptake of technetium-sulfur colloid in normal liver if cirrhosis suspected

• No vascular occlusion of portal system

Renal:

• Creatinine no greater than 1.5 mg/dL

• BUN no greater than 25 mg/dL

Other:

• No Crohn's disease, ulcerative colitis, or other inflammatory bowel disease

• Not pregnant

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• If prior chemotherapy, test dose of colloidal phosphorous P32 administered prior to attempted treatment

Endocrine therapy:

• Not specified

Radiotherapy:

• No prior radiotherapy to pancreas, liver, or upper gastrointestinal tract

Surgery:

• No complete surgical resection

• No splenectomy