Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Previously Untreated Stage I or Stage II Hodgkin's Lymphoma

• Status: Active, not recruiting
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to kill cancer cells. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with combination chemotherapy may kill more cancer cells. It is not yet known whether radiation therapy is more effective with or without combination chemotherapy in treating patients with Hodgkin's lymphoma.

PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works with or without combination chemotherapy in treating patients with previously untreated stage I or stage II Hodgkin's lymphoma.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
• Treatments: Bleomycin; Doxorubicin; Liposomal doxorubicin; Mechlorethamine; Prednisone; Procarbazine; Vinblastine; Vincristine

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed supradiaphragmatic Hodgkin's lymphoma

• Stage I or II disease

• Previously untreated disease

PATIENT CHARACTERISTICS:

• WHO performance status 0-2

• Normal life expectancy

• No severe cardiac, pulmonary, neurologic, or metabolic disease that would interfere with normal life expectancy or study treatment

• No other prior or concurrent malignancy except basal cell skin cancer or carcinoma in situ of the cervix

• No psychological, familial, socioeconomic, or geographic circumstance that would preclude proper staging or study compliance

• HIV negative

• Not pregnant

• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

• No prior staging laparotomy

• No prior biologic therapy, chemotherapy, endocrine therapy, radiotherapy, or surgery for this malignancy