Radiation Therapy and Temozolomide Followed by Temozolomide and Poly ICLC in Treating Patients With Newly Diagnosed GBM
Status:
Completed
Trial end date:
2010-04-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in
chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells,
either by killing the cells or by stopping them from dividing. Biological therapies, such as
poly ICLC, may stimulate the immune system in different ways and stop tumor cells from
growing. Giving poly ICLC after radiation therapy and temozolomide may stop any remaining
tumor cells from growing.
PURPOSE: This phase II trial is studying how well giving radiation therapy together with
temozolomide followed by temozolomide and poly ICLC works in treating patients with newly
diagnosed glioblastoma multiforme.
Phase:
Phase 2
Details
Lead Sponsor:
Sidney Kimmel Comprehensive Cancer Center Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins