Radiotherapy With or Without Concurrent Chemotherapy for Extensive Lymphatic Metastasis of Esophageal Cancer - 3JECROG P-03

• Status: Recruiting
• Trial end date: 2022-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The investigators aimed to compare elective nodal irradiation versus involved field irradiation with or without concurrent chemotherapy and the addition of consolidation chemotherapy for patients with extensive lymphatic metastasis of esophageal cancer.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese Academy of Medical Sciences
• Treatments: Albumin-Bound Paclitaxel; Paclitaxel

Criteria

Inclusion Criteria:

• Age<70

• Diagnosis of clinical stage T2-4N0-1M1（According to UICC 2002）

• A untreated squamous esophageal carcinoma

• Karnofsky performance status(KPS)≥ 70 and Charlson score ≤3

• Adequate organ function

• No known history of drug allergy

• Blood routine examination : WBC≥4.0

• hepatic and renal function are normal

Exclusion Criteria:

• Age≥ 70 or ≤ 16

• Already received the treatment of chemotherapy or radiotherapy

• Pregnant or lactating females

• Known drug allergy

• Without agreement of informed consent form

• Insufficient hepatorenal function or Blood routine examination

• Severe cardiovascular diseases, diabetes with uncontrolled blood sugar, mental disorders, uncontrolled severe infection, active ulceration which need intervention.