Ramosetron Versus Ondansetron for Radiotherapy Induced Nausea and Vomiting

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is:

1. To compare prophylactic effect of ondansetron versus ramosetron on radiotherapy induced nausea and vomiting in the treatment of gastrointestinal cancer.

2. To verify an improvement of 20% in complete response rate in term of radiotherapy induced nausea and vomiting (from 60% with ondansetron to 80% with ramosetron).

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seoul National University Hospital
• Treatments: Ondansetron; Ramosetron

Criteria

Inclusion Criteria:

• AJCC 1-3 staged gastrointestinal cancer patient

• patient undergoing radiotherapy as treatment

• age 20 yr and higher

• ECOG 0-2

Exclusion Criteria:

• age < 20

• ECOG 3-4

• patient experiencing nausea or vomiting prior to accrual

• patient under antiemetic medication

• patient under steroid medication (topical or inhalant steroid application are exceptional)

• patient under opioid medication