Randomised Controlled Study of Popofol Versus Midazolam as Sedation in Endoscopy With Advanced Liver Disease.

• Status: Unknown status
• Trial end date: 2018-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Gastrointestinal endoscopy is a frequent procedure in the patients with advanced liver disease. It requires variable degree of sedation ranging from minimal sedation to general anesthesia aiming for relieving pain, anxiety, and bad memories of the procedure.

In conscious sedation, patients are able to make purposeful responses to auditory and tactile clues, with maintenance of ventilatory and circulatory stability. while, in deep sedation, patients respond only to painful stimuli, and airway support is frequently required. At the level of general anesthesia, patients are unresponsive, and airway support is mandatory.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sherief Abd-Elsalam
• Collaborator: Tanta University
• Treatments: Fentanyl; Midazolam; Propofol

Criteria

Inclusion Criteria:

• Patients aged between 40 and 60 years old.

• With Child score B or C

• Presented for elective gastrointestinal endoscopy

Exclusion Criteria:

• Emergent condition like hematemesis.

• Patients with moderate to severe hepatic encephalopathy.

• Patients with hepatopulmonary syndrome.

• Patients with known or suspected hypersensitivity to the used medication were also excluded from the study.